Erythromycin

By T. Yugul. State University of New York College at Oswego. 2019.

Is it possible for the drug designer to exploit these existing control systems to deal with some pathological process? If there are no endogenous control systems buy erythromycin 250mg on line, how about identifying other targets on endogenous cellular structures or macromolecules that will permit control where endogenous control has not previously existed? Alternatively erythromycin 250 mg without prescription, instead of pursuing these endogenous approaches, it is sometimes easier simply to attack the cause of the pathology. If there is a harmful microorganism or toxin in the environment (exogenous), then it may be possible to directly attack this exogenous threat to health and inactivate it. Accordingly, this phase of drug development, which connects the drug–receptor interaction to human disease, may be divided into three logical approaches: 1. A full understanding of the three steps of phase 1 and the three approaches of phase 2 will enable the researcher to design drugs. A Drug as a Composite of Molecular Fragments For the practical implementation of this idealistic strategy, drug molecules are concep- tualized as being assembled from biologically active building blocks (biophores) that are covalently “snapped together” to form an overall molecule. Thus, a drug molecule is a multiphore, composed of a fragment that enables it to bind to a receptor (phar- macophore), a fragment that influences its metabolism in the body (metabophore), and one or more fragments that may contribute to toxicity (toxicophores). The drug designer should have the ability to optimize the pharmacophore while minimizing the number of toxicophores. To achieve this design strategy, these fragments or building blocks may be replaced or interchanged to modify the drug structure. Certain building blocks (called bioisosteres), which are biologically equivalent but not necessarily chemically equivalent, may be used to promote the optimization of the drug’s biological properties. Surgical procedures are labour intensive and time demanding; they help a limited number of individuals, one at a time, mostly in rich or developed nations. Medical therapy, on the other hand, is based on drug molecules and thus has the capacity to positively influence the lives of more people, often over a shorter time frame. Medical therapeutics offer hope in both developed and developing parts of the world—hopefully to rich and poor alike. Penicillin has saved countless lives through the effective treatment of devastat- ing infectious diseases. Before penicillin, a diagnosis of meningococcal meningitis was invariably a death sentence. Similarly, drugs for the treatment of high blood pressure have substantially reduced the impact of this “silent killer” that leads to myocardial infarction (heart attack) or cerebral infarction (stroke). It can be awe-inspiring to witness the effects of a seemingly trivial amount of drug. The panic-stricken child who cannot breathe because of an asthma attack gets prompt relief from the inhalation of a mere 100 micrograms of salbutamol sulphate. Uncontrolled and potentially life-threatening seizures (status epilepticus) in a young adult are quickly brought under control with the intravenous administration of 2 mg of lorazepam. The terrified older adult with crushing chest pain from a myocardial infarc- tion gains rapid relief from 8 to 10 mg of morphine. A medicinal chemist can help thousands or even millions of people with a carefully designed new drug molecule. The practice of science is a very human activity; medicinal chemistry is a humanitarian science. Every year, millions of new molecules are prepared, but only a very small fraction of these are ever considered as possible drug candidates. A chemical compound must possess certain characteristics if it is to cross the hurdle from being an organic molecule to becoming a drug molecule. In achieving this mandate, the medi- cinal chemist must design and synthesize new molecules, ascertain how they interact with biological macromolecules (such as proteins or nucleic acids), elucidate the rela- tionship between their structure and biological activities, determine their absorption and distribution throughout the body, and evaluate their metabolic transformations. Not sur- prisingly, medicinal chemistry is multidisciplinary, drawing on theoretical chemistry, organic chemistry, analytical chemistry, molecular biology, pharmacology, and bio- chemistry. Despite these complexities, medicinal chemistry has a clear “bottom line”— the design and discovery of drug molecules. A molecule is the smallest particle of a substance that retains the chemical identity of that substance; it is composed of two or more atoms held together by chemical bonds (i. Although molecules are highly variable in terms of struc- ture, they may be organized into families on the basis of certain groupings of atoms called functional groups. It is the presence of functional groups that determines the chemical and physical properties of a given family of molecules. The structure of the drug molecule thus per- mits a desired biological response, which should be beneficial (by inhibiting patholog- ical processes) and which ideally precludes binding to other untargeted receptors, thereby minimizing the probability of toxicity. The framework upon which the func- tional groups are displayed is typically a hydrocarbon structure (e. The structural framework should also be relatively rigid (“conformationally constrained”) to ensure that the array of functional groups is not flexible in its geome- try, thus preventing the drug from interacting with untargeted receptors by altering its molecular shape.

Seborrheic dermatitis is characterized by red scaly lesions predominantly located on the scalp trusted erythromycin 250mg, face generic erythromycin 250mg amex, and upper trunk. The skin lesions are distributed on the scalp, eyebrows, nasolabial folds, cheeks, ears, pre- sternal and interscapular regions, axillae, and groin. Around 90 to 95% of all patients have scalp lesions and lesions on glabrous skin are found in approxi- mately 60% of the patients. Complications include lichenification, secondary bacterial infection, and otitis externa. A seasonal variation is observed with the majority of patients being better during the summertime. Seborrheic dermatitis is seen more frequently than expected in 197 198 Faergemann patients with pityriasis versicolor, Pityrosporum folliculitis, Parkinson’s disease, major truncal paralysis, mood depression, and acquired immunodeficiency syn- drome (1). Many treatment studies de- scribe the effectiveness of antimycotics, which reduces the number of P. The increased inci- dence of seborrheic dermatitis in patients with immunosuppressive disorders sug- gests that the relationship between P. Elevated titers in patients compared to controls as well as no difference in titers have been reported (3,4). In patients with seborrheic dermatitis, a reduced lymphocyte transformation response com- pared to healthy controls has been reported in two studies (5,6). However, in another study an enhanced lymphocyte stimulation response compared to healthy controls was found (7). In two recently published studies, no difference in lym- phocyte stimulation response was found between patients with seborrheic derma- titis and healthy controls (8,9). In an immunological screening of patients with seborrheic dermatitis, we have found low ( 0. In an immunohistochemical study in patients with seborrheic dermatitis deposits of complement C3c and IgG were found in the stratum corneum below Seborrheic Dermatitis 199 clusters of P. The local immune response in the skin may be different from the results obtained from in vitro studies on peripheral blood mononu- clear cells and may better explain the inflammatory skin reaction seen in seborrheic dermatitis. In a recently fulfilled immunohistochemical study (data are still unpublished), we found an increase in all cellular markers in both le- sional and nonlesional skin from patients with seborrheic dermatitis. It is important that no major differences were seen in the number of interleukin-associated cells between lesional and nonlesional skin in seborrheic dermatitis. The immune response in the skin of pati- ents with seborrheic dermatitis is complex, but showed some similarities with the results obtained with Candida infections (14,15). This is probably one of the important ex- planations why the immune response in the skin is more complex with dis- eases where this organism is involved. A strong stimulation of cells with natural killer function and complement activity may partly be explained by various enzymes (e. Stress and winter climate have a negative effect on the majority of patients and summer and sunshine have a posi- tive effect. In patients with neurological diseases and especially in patients with immunosuppressive disorders, seborrheic dermatitis is more resistant to therapy. Antifungal therapy is effective in the treatment of seborrheic dermatitis and, because it reduces the number of P. In one study, the com- bination of hydrocortisone and miconazole in an alcoholic solution was signifi- cantly more effective than hydrocortisone alone in reducing the number of P. Oral keto- conazole has been effective in a double-blind, placebo-controlled trial in patients with seborrheic dermatitis of the scalp and other areas (18). However, oral ketoco- nazole should be reserved for patients not responding to topical therapy. In an- other double-blind, placebo-controlled study, ketoconazole 2% cream has been effective in the treatment of seborrheic dermatitis of the scalp and face (17), and in a comparative study between ketoconazole and hydrocortisone cream no difference was seen in effectiveness (20). Ketoconazole shampoo used twice weekly is very effective in treating seborrheic dermatitis of the scalp (18). In a double-blind placebo-controlled study of ketoconazole shampoo used twice weekly for 4 weeks, 89% in the ketoconazole group was cured, compared with only 14% in the placebo group (18). Ketoconazole used once weekly has also been effective in preventing re- currence of dandruff in previously treated patients. Ketoconazole shampoo has been compared to ciclopirox olamine shampoo in the treatment of seborrheic dermatitis/dandruff (24). Both shampoos were equally effective and significantly more effective than placebo. However, at a follow-up visit 2 weeks after cessation of treatment, the recurrence rate was significantly lower in the ketoconazole group compared to the ciclopirox olamine group (24). Other topical antimycotics are effective in the treatment of seborrheic der- matitis (2,16,21–25). Shampoos containing zinc pyrithione (21), selenium sulfide (16), or bifonazole (25) are also effective and widely used. In severe inflammatory seborrheic dermatitis, topical treatment with anti- fungal therapy alone may not be effective. Another therapy that can be effective is to combine potent topical corticosteroids with topical antifungal therapy.

Does it mean that the miracidia by themselves can start ortho-phospho-tyrosine forming? Or had there been an adult in the liver recently to start it all cheap erythromycin 500 mg with amex, but then got killed somehow? Could the Sheep liver fluke also induce a cancer by starting ortho-phospho-tyrosine formation? Summary: This was certainly a happy ending for us since we had waited anxiously to hear what might have happened to her generic erythromycin 500 mg free shipping. We were not at all sure she was complying with instructions after the first visit. But her intelligence (and perhaps a little fear) saw her safely through this ordeal. She had the deadly benzene solvent in her, and it was difficult for her to believe it was in her toothpaste. He seemed to have enough determination for us to let him start his second program, the kidney herbs, on his own without visiting the office in between. But he begged for progress with his pain when sitting and lives two states away, too far away for frequent visits. The Tamoxifen was given to her to block estrogen uptake after she had a mastectomy on the right side. She will start her pet on pet parasite program and herself on the human parasite program. She will give herself a 3 day high dose program and then maintenance parasite treatment. She needs all amalgam fillings out of her mouth, all aluminum out of her kitchen, and the water softener taken out. She is dissolving her tooth fillings but instead of passing the metals through the kidney and bowel they are staying stuck in her breast. She probably has numerous kidney stones from all this which, in turn, then slow down excretion. She is full of solvents; no doubt her detoxifying mechanisms are so overtaxed that no solvent can be oxidized any more. She was given interleukin 1 and interleukin 2 plus Interferon shots for her mul- tiple kidney tumors. The other kidney was removed, full of tumors, 2 years ago, and at the same time half of her thyroid was removed for renal cell carcinoma. She was very pleased with how she felt and could not believe these simple herbs succeeded where in- terleukin and interferon had failed Hopefully, she is staying on our meat rule (beef turkey, and chicken must be cooked at home, as well done as if it were pork, never grilled And only fish or seafood in restaurants). Another possibility is that his intestinal flukes were somehow killed while the stages survived in the blood. He will stop abrasive brushing and will use strong salt water and food grade hydrogen peroxide for brushing instead. It could, of course, be in his water supply if there is galvanized piping, but we will try to emphasize the smoking first, for his sake. His lung le- sions will probably continue to enlarge, and he may not get his foot pain relieved without stopping. We may not see him again, though, since heavy emphasis on stopping addictions loses us nearly every cli- ent. He has tried every medication given by clinical doctors, as well as over-the-counter products. Also, any little sore he gets from his work (he works with lumber) does not heal for a long time. One month later He says there is some improvement but some lesions, especially on legs, are two years old! If all the people with this problem were to join hands, could they persuade authorities to protect them? Her clinical doctors found she had 80% blockage of carotid arteries and leg arteries. She chose chelation instead of standard clinical treatment but stopped after 60 treatments without responding. Summary: A ten year torment was ended in 2 weeks by killing this large parasite that had invaded so much of her body; it is a wonder she was alive to tell the story. Possibly all her alternative therapies helped her to survive, each in its own way. She was undoubtedly reinfecting herself many times and letting parasites proliferate due to having the two worst solvents accumulated in her. Esther Santos Breast Cancer This 49 year old woman came to the office for a list of peculiar symptoms: numbness of lips, arms and tip of tongue occasionally. Her clinical doctor diagnosed pulmonary angina and put her on 2 aspirins a day for the last 4 months. She had a polyp in a milk duct in her right breast removed a year ago and another one in the left cheek sinus, not removed.

In parturition it is not so immediate or forceful as ergot buy 250mg erythromycin free shipping, but acts mildly in the same manner purchase erythromycin 250 mg on line. In uterine subinvolution, in menorrhagia or metrorrhagia from this cause, it is the best remedy we have. It is useful also in post-partum hemorrhage, but is rather slow in its action when immediate results are demanded. In the incipient stage of the development of tumors within the uterine structure, or fibroid growths, it is not excelled by ergotine. It may be used hypodermically in these cases, and its results are comparatively permanent. He uses the mother tincture in conjunction with conium, giving five drops at a dose three or four times a day, the hydrastis before, the conium after meals. He says: “Sometimes, I mix them and give ten drops of the mixture three times a day. Where the swelling is soft or undulated and painful on pressure, and pain extending into the axilla, we find phytolacca in the same doses better than either. Sometimes, all three remedies are good together, and none of them is valuable in the open cancer. The remedies must be continued a long time to make a decided impression, and their effect is even increased by the same remedies being applied externally in the form of a plaster. In all catarrhal conditions, especially if there be muscular relaxation and general enfeeblement, it is a useful remedy. It is used locally in solution and is of much value as an application wash, irrigating fluid or gargle in all such catarrhal, ulcerating, aphthous, indolent and otherwise unhealthy conditions of mucous surfaces. It is a most useful gargle in aphthous or ulcerated sore mouth, in conditions where the gums are spongy or loosened from the teeth or bleed easily. Ellingwood’s American Materia Medica, Therapeutics and Pharmacognosy - Page 256 Ten minims of a fluid preparation, to the ounce, may be used, or a solution of the hydrochlorate of hydrastine in nasal catarrh, in inflammation of the eyes and in gonorrhea One grain of the hydrochlorate in an ounce of rose water, with or without five grains of the sulphate of zinc, is of superior value in purulent conjunctivitis. The same preparation, diluted, is useful in gonorrhea Five drops of the solution in a dram of warm water is the proper strength. The colorless hydrastis in a solution with a small quantity of the potassium chlorate is sometimes superior in nasal catarrh. It is the best of washes in leucorrhea, whatever the cause, and it can be used freely without danger and in various strengths—from one dram to three, to the pint of hot water. It is of much service when the discharge is thick, yellow, and the membranes relaxed and feeble. It forms an excellent wash in eczema of the anus, with ulcers or fissures within the rectum. Its use may be followed with the application of a zinc ointment, with twenty-five per cent its weight of bismuth subnitrate. In mild solutions of the hydrochlorate of the alkaloid one-fourth grain to the ounce, it is serviceable in catarrh of the bladder, as an irrigating fluid. We find in addition to the tonic influence of this remedy, that it has been used in a number of cases of gall stone, with curative results. Professor Farnum claims to have cured a number of cases with the powdered hydrastis. The cases which he regards amenable to this treatment are, first, ordinary cases of cholelithiasis, where the symptoms are transient and not severe; second, acute inflammatory cases, usually attended with fever, and catarrhal conditions of the gall ducts; third, cases ordinarily called biliary colic. Those, of course, where organic change has not taken place, or where the stones are not impacted, in the gall bladder or in the ducts. He uses it as an efficient remedy in catarrhal jaundice where there is no pain to indicate the presence of gall stones in the ducts. This is in harmony with its influence on general catarrhal conditions of the gastro-intestinal tract. Goss claimed that it had direct catalytic power, and aided the digestion, while it corrected the biliary function. It restores the mucous lining of the gall duct, in the same manner that it influences other mucous surfaces. Ellingwood’s American Materia Medica, Therapeutics and Pharmacognosy - Page 257 Cuthberton gave hydrastis canadensis as a tonic to a pregnant woman who had a goitre of recent appearance. As a result of this observation, he treated twenty-five other cases of goitre at the time of puberty, or during the pregnant state. At times when interference with the function of the reproductive organs seemed to produce reflex irritation. One of the patients had become steadily worse under the use of iodine, the iodides, and thyroid extract. This patient began to improve as soon as hydrastis was given, and was promptly cured with this remedy alone. It has been reported as a remedy for mammary cancer, but its more satisfactory influence is upon painful fulness of the mammary gland, during the menstrual period, or for the treatment of local enlargements occurring more or less suddenly, of a benign character, either in maiden ladies or at the menopause.

Best The Archer Mini Amplifier Speaker is inexpensive and small (about the size of a transistor radio) discount erythromycin 250 mg, making it easy to take with you cheap 250 mg erythromycin otc. Remove the screw at the center back of the speaker using a Phillips screw driver to gain access to the battery compartment. If there are no holes use alliga- tor clip leads, but slip a piece of plastic tape between the posts to make sure the alligator clips do not touch each other. A dermatron is a device invented dec- ades ago to measure body resistance (as opposed to skin resistance which is what lie detectors measure). The Easy Way Circuit Build The Electrosonic Human (in the 200 in One Elec- tronic Project Lab by Science Fair, Cat. If your kit has a different catalog number you may have different connection numbers. Instead of connecting the probe to terminal T2, just clip it directly to terminal 137, and remove the 137-T2 wire. Simi- larly, clip the handhold to terminal 76 and remove the 76-26 and 25-T1 wires. Later, when you use the probe to press against your knuckle you may find it painful. Positive (the short post, if using the 1/8 inch phono jack) goes to 53, and negative (long post) goes to 54. If it does not, check that your alligator clips are not bending the spring terminals so much that other wires attached there are loose. Get a shoe box, save the lid, photocopy the picture in this book and tape it to the bottom (inside) of the box. Mount the light switch (a) just like you did for the test plates on the front of the shoe box. Pierce a hole with a large nail or pencil for the shaft of the potentiometer (b), and a smaller hole for the tab on the side of the potentiometer (the tab keeps the potentiometer from rotating when you turn the switch). Remove the nut and washer from the base of the potentiometer shaft, in- sert the shaft into the hole from the inside of the shoe box. When the ceramic part is almost touching the box, bend the wires inside to keep it in place. The ca- pacitors look very much alike, so be careful not to switch them (open one capacitor package at a time and put the part directly in place, double checking the diagram). Hold it in your left hand with the flat side on the left and wires pointing up at you. Bend the base wire away to the left slightly so you will be able to insert the transistor into the triangle of holes. A diagram on the transistor package tells you that the top wire is the “collector” and the bottom wire is the “emitter”. Insert the transistor from the outside of the box so each wire goes where it is supposed to, and bend the wires sideways to secure. If they are not, strip away ¼ inch of insulation and twist the strands together on each wire to keep them neat (practice using the wire stripper, first, on a different piece of wire). Push them through the box and bend them down with a knife or screwdriver on the inside to keep the trans- former firmly in place or tape the transformer to the out- side of the box. You will only use three batteries, so in one of the battery slots, fill the space with a paper clip. Hook the other end to the spring, and thread the straight part through the hole on the other side. In the picture there are both mini- hook and alligator clips depicted, but it is not important which kind you use, only that you make secure connec- tions. The speaker should produce a sound like popping corn (readjust speaker volume to a comfortable level). Now turn the knob almost fully counter-clockwise, mark the box, and listen to this pitch. After you have used the Syncrometer for a while you may wish to take your device to an electronics shop and ask some- one to mount the components in an all plastic box and solder the connections. This would let you travel with it in your suit- case without mashing it into a jumbled mess of wires. Using another alligator clip connect the other screw terminal to your other test surface (the “tissue plate”). You were probably trained to listen for a slight current in- crease when testing substances. The concept was if the sub- stance was anywhere in the body there would be higher conductance.

These clots make “nests” for fluke stages which may be why breast lumps often become cancerous discount 500mg erythromycin free shipping. If yours is over 300 order erythromycin 250 mg without a prescription, (it should be 250,000/cu mm) start patrolling parasites regularly. They cleared up in weeks after her dental metal was gone (she simply took out her retainer). Her estrogen level was too high (187 pg/ml on day 22 of her cycle; the day of testing is important since it varies through the cycle). After she did the kidney and Liver Cleanse, the lumps got softer and breasts were no longer painful. She had several root canals which filled her breasts with numerous bacteria, mainly Histoplasma cap (root canals develop infection around themselves). After starting her dental cleanup and killing bacteria with a frequency generator, all her breast lumps disappeared. Claudia Davis, age 41, had breast soreness ever since a mammogram two years earlier. She had a buildup of niobium from polluted pain killer drugs and thulium from her vitamin C. She had Salmonella and several other bacteria in her white blood cells, which accounted for digestive problems. In eight weeks she had cleaned kidneys, killed parasites and gotten rid of her heavy met- als. Stephanie Nakamura, 68, had six surgeries to remove breast lumps, going back to youth. Her breasts were toxic with cadmium, lead, gold, radon, uranium, gal- lium, silver. Our tests showed she had kidney crystals and she was started on the kidney cleanse. She was given vitamin E, (400 units daily), sodium selenite (150 mcg daily) and vitamin C (1 or more grams daily). She was given magnesium (300 mg daily), vitamin B6 (250 mg daily) and lysine (500 mg daily). She killed parasites and cleaned up everything except gallium, silver, mercury, gold, cadmium. Her dentist advised against removing these and proclaimed they had nothing to do with her developing glaucoma, arthritis and stomach ulcers. Perhaps if she had been up for the next breast surgery she would have gotten those “gold” crowns replaced with composite too. It often begins as a pain just above the heart but spreads itself over the whole heart region. Another heart parasite, Loa loa, is also a filarial worm and may be the causative factor. Both Dirofilaria and Loa loa can be obtained as slide specimens to use for testing yourself. Heart muscle can also be obtained as a slide specimen, but a chicken heart from the grocery store or snippets of beef heart (make sure to sample all 4 chambers) will do. These stages, if not killed, will become adults so a maintenance parasite killing program, herbal or electronic, is essential. They pick it up immediately after their last treatment for it and can give it to you again. The only way to live safely with pets is to give them parasite killing herbs daily in the feed. Other heart problems such as irregular beat and mitral valve prolapse can clear up along with the pain. She owned a beautiful, old, very big dog, and of course she would never part from him. She had both Dirofilaria and Loa loa which we killed instantly with a frequency generator. We found she also had Cytomegalovirus, Staphylococcus aureus, Streptococcus pneumonia in her heart. She repeated everything, then she had to go off her heart medications because they lowered her blood pressure and pulse too much. She started the dog on the parasite program but continued to be heavily laden with parasites and bacteria that always found their way to her heart. She purchased her own fre- quency generator and was quite faithful with dog treatments. She had Dirofilaria, high levels of styrene (from sty- rofoam drinking cups) and benzene. Five weeks after starting the parasite program she was feeling much better but still had the chest pain.

Some notes on this recipe: this herbal tea buy erythromycin 500 mg lowest price, as well as the parsley generic erythromycin 500mg with amex, can easily spoil. Heat it to boiling every fourth day if it is being stored in the refrigerator; this resterilizes it. If you ster- ilize it in the morning you may take it to work without refriger- ating it (use a glass container). If the ones you buy are barely fragrant, they have lost their active in- gredients; switch to a different supplier. If you can only find several of those in the recipe, make the recipe anyway; it will just take longer to get results. Remember that vitamin B6 and magnesium, taken daily, can prevent oxalate stones from forming. Phosphate levels are high in meats, breads, cereals, pastas, and carbonated drinks. You can dissolve all your kidney stones in 3 weeks, but make new ones in 3 days if you are drinking tea and cocoa and 68 Taken from Food Values 14ed by Pennington and Church 1985. Liver Herbs Don’t confuse these liver herbs with the next recipe for the Liver Cleanse. This recipe contains herbs traditionally used to help the liver function, while the Liver Cleanse gets gallstones out. Liver Cleanse Cleansing the liver of gallstones dramatically improves di- gestion, which is the basis of your whole health. But it should not be done before the parasite program, and for best results should follow the kidney cleanse. The liver is full of tubes (biliary tubing) that deliver the bile to one large tube (the common bile duct). The gallbladder is attached to the common bile duct and acts as a storage reser- voir. Eating fat or protein triggers the gallbladder to squeeze itself empty after about twenty minutes, and the stored bile fin- ishes its trip down the common bile duct to the intestine. For many persons, including children, the biliary tubing is choked with gallstones. Not only that, most are too small and not calcified, a prerequi- site for visibility on X-ray. There are over half a dozen varieties of gallstones, most of which have cholesterol crystals in them. Other stones are compos- ites–made of many smaller ones–showing that they regrouped in the bile ducts some time after the last cleanse. At the very center of each stone is found a clump of bacte- ria, according to scientists, suggesting a dead bit of parasite might have started the stone forming. Much less water would flow, which in turn would decrease the ability of the hose to squirt out the marbles. With gallstones, much less cho- lesterol leaves the body, and cholesterol levels may rise. Gallstones, being porous, can pick up all the bacteria, cysts, viruses and parasites that are passing through the liver. In this way “nests” of infection are formed, forever supplying the body with fresh bacteria and parasite stages. No stomach infection such as ulcers or intestinal bloating can be cured permanently without removing these gallstones from the liver. For best results, ozonate the olive oil in this recipe to kill any parasite stages that may be released during the cleanse. Zap daily the week before, or get through the first three weeks of the parasite killing program before attempting a liver cleanse. If you are on the maintenance parasite program, you are always ready to do the cleanse. You want your kidneys, bladder and urinary tract in top working condition so they can efficiently remove any undesirable substances inci- dentally absorbed from the intestine as the bile is being excreted. Ingredients Epsom salts 4 tablespoons Olive oil half cup (light olive oil is easier to get down), and for best results, ozonate it for 20 to 30 minutes, first Fresh pink grapefruit 1 large or 2 small, enough to squeeze 2/3 to 3/4 cup juice Ornithine 4 to 8, to be sure you can sleep. Pint jar with lid Black Walnut Tincture, any 10 to 20 drops, to kill parasites strength. Choose a day like Saturday for the cleanse, since you will be able to rest the next day. Eat a no-fat breakfast and lunch such as cooked cereal, fruit, fruit juice, bread and preserves or honey (no butter or milk). Set the jar in the refrigerator to get ice cold (this is for convenience and taste only). Close the jar tightly with the lid and shake hard until watery (only fresh grapefruit juice does this). Take 4 orni- thine capsules with the first sips to make sure you will sleep through the night.